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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell. 2014 Jun 5;157(6):1279–1291. doi: 10.1016/j.cell.2014.03.065

Figure 1. Muscle-specific PGC1α4 transgenic mice are lean and display increased thermogenesis in the adipose tissue.

Figure 1

See also Figure S1 (A) Representative images of epi fat from wild-type (WT) or Myo-PGC1α4 mice. (B) Determination of SubQ, Epi and BAT weights from WT (N=5) and Myo-PGC1α4 mice (N=7). (C) Determination of percent fat mass between WT and Myo-PGC1α4 mice using MRI (N=6). (D) Body weights of WT and Myo-PGC1α4 mice upon challenging with HFD starting at 4 weeks (N=10). (E, F) Real-time PCR (qPCR) analysis of markers associated with thermogenic, mitochondrial and β-oxidation genes in (E) subQ, and (F) epi adipose tissue of WT and Myo-PGC1α4 (N=6). *p<0.05, **p<0.001, ***p<0.0001. All data are presented as mean +/− s.e.m.