Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Oct;76(10):5350–5354. doi: 10.1073/pnas.76.10.5350

Abelson antigen is expressed on hematopoietic spleen colony-forming cells from mice carrying the Av-2S virus sensitivity gene.

R Risser
PMCID: PMC413140  PMID: 228287

Abstract

Abelson antigen is a cell-surface determinant specifically induced by the Abelson murine leukemia virus (A-MuLV); this antigen is also expressed on uninfected bone marrow of BALB/c mice. Antisera that contained antibody to Abelson antigen were cytotoxic for the spleen colony-forming cells (CFU-S) of adult bone marrow from BALB/c mice. Absorption tests with appropriate tissues and direct cytotoxic tests with bone marrow CFU-S from several mouse strains confirmed that the sensitivity of BALB/c CFU-S to lysis by anti-Abelson-antigen antisera was due to expression of Abelson antigen. Spleen or bone marrow from BALB/c mice undergoing hematopoietic regeneration amplified Abelson antigen expression, although no expression of Abelson antigen was observed on regenerating C57BL/B6 bone marrow or spleen. The presence of Abelson antigen on bone marrow cells of seven recombinant inbred strains coincided with the inheritance of sensitivity alleles at the Av-2 locus, a gene that determines susceptibility to A-MuLV lymphoma induction. These results indicate that expression of Ableson antigen may have a physiologic function in hematopoietic differentiation and a pathologic role in A-MuLV lymphomagenesis.

Full text

PDF
5350

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abelson H. T., Rabstein L. S. Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Res. 1970 Aug;30(8):2213–2222. [PubMed] [Google Scholar]
  2. Abramson S., Miller R. G., Phillips R. A. The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med. 1977 Jun 1;145(6):1567–1579. doi: 10.1084/jem.145.6.1567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BECKER A. J., McCULLOCH E. A., TILL J. E. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963 Feb 2;197:452–454. doi: 10.1038/197452a0. [DOI] [PubMed] [Google Scholar]
  4. Bailey D. W. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation. 1971 Mar;11(3):325–327. doi: 10.1097/00007890-197103000-00013. [DOI] [PubMed] [Google Scholar]
  5. Boss M., Greaves M., Teich N. Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristics. Nature. 1979 Apr 5;278(5704):551–553. doi: 10.1038/278551a0. [DOI] [PubMed] [Google Scholar]
  6. Hartley J. W., Rowe W. P. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology. 1975 May;65(1):128–134. doi: 10.1016/0042-6822(75)90013-6. [DOI] [PubMed] [Google Scholar]
  7. Lala P. K., Johnson G. R. Monoclonal origin of B lymphocyte colony-forming cells in spleen colonies formed by multipotential hemopoietic stem cells. J Exp Med. 1978 Dec 1;148(6):1468–1477. doi: 10.1084/jem.148.6.1468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  9. MCCULLOCH E. A., TILL J. E. PROLIFERATION OF HEMOPOIETIC COLONY-FORMING CELLS TRANSPLANTED INTO IRRADIATED MICE. Radiat Res. 1964 Jun;22:383–397. [PubMed] [Google Scholar]
  10. O'Donnell P. V., Stockert E. Induction of GIX antigen and gross cell surface antigen after infection by ecotropic and xenotropic murine leukemia viruses in vitro. J Virol. 1976 Dec;20(3):545–554. doi: 10.1128/jvi.20.3.545-554.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. OLD L. J., BOYSE E. A., STOCKERT E. TYPING OF MOUSE LEUKAEMIAS BY SEROLOGICAL METHODS. Nature. 1964 Feb 22;201:777–779. doi: 10.1038/201777a0. [DOI] [PubMed] [Google Scholar]
  12. Old L. J., Stockert E. Immunogenetics of cell surface antigens of mouse leukemia. Annu Rev Genet. 1977;11:127–160. doi: 10.1146/annurev.ge.11.120177.001015. [DOI] [PubMed] [Google Scholar]
  13. Potter M., Sklar M. D., Rowe W. P. Rapid viral induction of plasmacytomas in pristane-primed BALB-c mice. Science. 1973 Nov 9;182(4112):592–594. doi: 10.1126/science.182.4112.592. [DOI] [PubMed] [Google Scholar]
  14. Pratt D. M., Strominger J., Parkman R., Kaplan D., Schwaber J., Rosenberg N., Scher C. D. Abelson virus-transformed lymphocytes: null cells that modulate H-2. Cell. 1977 Nov;12(3):683–690. doi: 10.1016/0092-8674(77)90268-9. [DOI] [PubMed] [Google Scholar]
  15. Raschke W. C., Baird S., Ralph P., Nakoinz I. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell. 1978 Sep;15(1):261–267. doi: 10.1016/0092-8674(78)90101-0. [DOI] [PubMed] [Google Scholar]
  16. Risser R. Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus. J Exp Med. 1979 May 1;149(5):1152–1167. doi: 10.1084/jem.149.5.1152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Risser R., Potter M., Rowe W. P. Abelson virus-induced lymphomagenesis in mice. J Exp Med. 1978 Sep 1;148(3):714–726. doi: 10.1084/jem.148.3.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Risser R., Stockert E., Old L. J. Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918–3922. doi: 10.1073/pnas.75.8.3918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
  20. Scher C. D., Siegler R. Direct transformation of 3T3 cells by Abelson murine leukaemia virus. Nature. 1975 Feb 27;253(5494):729–731. doi: 10.1038/253729a0. [DOI] [PubMed] [Google Scholar]
  21. Scolnic E. M., Goldberg R. J., Parks W. P. A biochemical and genetic analysis of mammalian RNA-containing sarcoma viruses. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):885–895. doi: 10.1101/sqb.1974.039.01.103. [DOI] [PubMed] [Google Scholar]
  22. Sharkis S. J., Wiktor-Jedrzejczak W., Ahmed A., Santos G. W., McKee A., Sell K. W. Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice. Blood. 1978 Oct;52(4):802–817. [PubMed] [Google Scholar]
  23. Siden E. J., Baltimore D., Clark D., Rosenberg N. E. Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell. 1979 Feb;16(2):389–396. doi: 10.1016/0092-8674(79)90014-x. [DOI] [PubMed] [Google Scholar]
  24. Sklar M. D., Shevach E. M., Green I., Potter M. Transplantation and preliminary characterisation of lymphocyte surface markers of Abelson virus-induced lymphomas. Nature. 1975 Feb 13;253(5492):550–552. doi: 10.1038/253550a0. [DOI] [PubMed] [Google Scholar]
  25. Staber F. G., Schläfli E., Moroni C. Expression of endogenous C-type viral antigen on normal mouse haemopoietic stem cells. Nature. 1978 Oct 19;275(5681):669–671. doi: 10.1038/275669a0. [DOI] [PubMed] [Google Scholar]
  26. Stockert E., Old L. J., Boyse E. A. The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med. 1971 Jun 1;133(6):1334–1355. doi: 10.1084/jem.133.6.1334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. TILL J. E., McCULLOCH E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961 Feb;14:213–222. [PubMed] [Google Scholar]
  28. Witte O. N., Rosenberg N., Paskind M., Shields A., Baltimore D. Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci U S A. 1978 May;75(5):2488–2492. doi: 10.1073/pnas.75.5.2488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wu A. M., Till J. E., Siminovitch L., McCulloch E. A. A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells. J Cell Physiol. 1967 Apr;69(2):177–184. doi: 10.1002/jcp.1040690208. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES