Table 1.
Complexing ion |
Gefitinib mM ±s.d. |
Phospholipid mM ±s.d. |
Drug:Lipid Ratio ±s.d. |
|||
---|---|---|---|---|---|---|
Initial† | Final | Initial | Final | Initial | Final | |
Citrate | 2.21 ±0.23 | 0.87 ±0.02 | 10.50 ±0.30 | 5.55 ±0.67 | 0.21 ±0.03 | 0.16 ±0.02 * |
Ammonium Sulfate | 2.12 ±0.24 | 1.08 ±0.26 | 11.39 ±0.34 | 5.69 ±0.12 | 0.19 ±0.02 | 0.19 ±0.04 |
Tris/NaCl | 4.59 ±1.88 | 0.23 ±0.01 | 18.35 ±0.67 | 7.67 ±0.29 | 0.25 ±0.11 | 0.03 ±0.002 * |
Free Drug | 1.51 ±0.78 | 0.25 ±0.01 | - | - |
s.d.: standard deviation
n=triplicate determinations for each sample
Decreased significantly from initial value (p<0.05)