Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Nat Immunol. 2014 May;15(5):415–422. doi: 10.1038/ni.2872

Figure 3. AGS Genes Restrict Replication of Endogenous Retroelements and Exogenous Retroviruses.

Figure 3

Schematic of LINE and Retrovirus Replication. AGS genes act throughout the steps of replication to restrict products of reverse transcriptase. SAMHD1 inhibits reverse transcription through degradation of cellular dNTPs. TREX1 metabolizes DNA products of reverse transcription, and can block retrotransposition of endogenous retroelements. RNASEH2 can degrade RNA of RNA/DNA hybrids and can also block retrotransposition of endogenous retroelements, and we hypothesize that it acts by degrading viral RNA in the context of reverse transcription.