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. 2014 Aug 1;10:50. doi: 10.1186/1744-8069-10-50

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Copyright © 2014 Rowan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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SNC80 and ARM390 are equally effective at inhibiting N-type voltage-gated calcium currents in primary sensory neurons. TG neurons from rats were nucleofected with rat DOPr-YFP cDNA and N-type voltage-gated calcium currents were recorded 24–48 h after isolation. Maximal current amplitudes were observed between −10 and −5 mV. Control currents were recorded first in SES with 0.1% DMSO (Vehicle). Following bath application of SNC80 (1 μM, 5 min) currents were again recorded. Cells that responded to SNC80 were washed with SES (5 min) and currents were recorded again prior to bath application of ARM390 (1 μM, 5 min) and final current measurement. Representative single cell current–voltage curves (A) and the mean ± SEM extent of current inhibition (expressed as % inhibition) for 10 and 12 cells for SNC80 and ARM390, respectively (B).