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. 2014 Aug 1;10:50. doi: 10.1186/1744-8069-10-50

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Copyright © 2014 Rowan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chronic administration of SNC80, not ARM390, results in behavioral symptoms of opioid-induced hyperalgesia in rats, not mice. A & C) Following baseline thermal testing (Pre), separate groups of rats (A) and mice (C) received intraplantar injections once daily for 5 days with SNC80 (20 μg rats, 10 μg mice), ARM390 (20 μg rats, 10 μg mice), or vehicle (4% DMSO, 2% Tween20, PBS). On day 6 (Post), animals were re-tested for thermal sensitivity at least 24 h after the last injection. ***p > 0.001 by two-way ANOVA. B & D) Following thermal testing on day 6, animals received an intraplantar injection of capsaicin (0.5 μg rats, 0.1 μg mice) and nocifensive behavior was quantified for 5 min. **p > 0.01 by one-way ANOVA. n.s. = not significant.