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. 2014 Jul 24;2014:921954. doi: 10.1155/2014/921954

Figure 5.

Figure 5

Time-course changes in mRNA levels of osteogenesis-related genes in rat bone marrow stromal cells (rBMSCs) at 6 h, 12 h, 24 h, 36 h, or 48 h after osteogenic culture treated with 10−5 M 7-methoxycoumarin or osthole or neither (control). Levels of expression were determined by qRT-PCR and are presented as fold changes relative to the control after being standardized against internal control GAPDH. (a) IGF-1; (b) Runx-2; (c) Osterix; (d) OPG; (e) RANKL; (f) OPG/RANKL. Results are expressed as the mean ± SD, *P < 0.05, **P < 0.01 versus control; # P < 0.05, ## P < 0.01 versus 7-methoxycoumarin.