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The role of Hsp70 and Hsp90 chaperone in the regulation of tau protein. The dephosphorylation and refolding of protein tau is facilitated by Hsp70/90 complex, preventing degradation; when the Hsp90 inhibition is initiated, tau is transferred to the Hsp70/CHIP complex undergoing degradation. The inhibition of Hsp90 promotes the depolymerization of Hsp90-containing HSF1 complex and induces HSF1 into homotrimer to activate HSP gene expression.
