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. 2012 Jun;1(2):78–88. doi: 10.3978/j.issn.2223-4683.2012.05.06

Table 2. Methylated genes in prostate cancer whose regulation by TGF-β is not yet known.

Name Function Reference
1. HLAa HLA class-I antigen (41)
2. ERβ Estrogen receptor (67)
3. ERα Estrogen reeptor (67)
4. AR Androgen receptor (67)
5. RARβ Tumor suppressor (67)
6. DAPK1 Regulate cell death (118)
7. MDR1 Multi-drug resistant gene (41,119)
8. APC Antagonist of Wnt (41,119-121)
9. CD44 Cell migration and adhesion (52,57)
10. MCAM (MUC18, CD146) In advanced PCa (41,122)
11. TIG1 Retinoic acid receptor responder (41,123)
12. THRB Thyroid hormone receptor B (41)
13. Laminin-5 Role in adhesion and motility (124)
14. WIF1 Wnt inhibitory factor (125-127)
15. TSLC1 Tumor suppressor (128)
16. RIZ1 Rb-interacting zinc finger gene 1 (73,129)
17. Cyclin D2 (or CCND2) Regulate cell cycle (54,67,130)
18. GSTP1 Cell detoxification (4,7,121,131)
19. PDLIM4 Actin binding protein, tumor suppressor (41,132)
20. Sprouty1 negative regulators of MAPK/PI3K (133)
21. ZNF331 Tumor suppressor (134)
22. TMS1(ASC, PYCARD) Induces apoptosis by caspase (57,73,135)
23. GPX3 Anti-oxidant (82,119
24. NKX2.5 Repress calreticulin expression (41)
25. NKX3.1 Promotes normal differentiation (136)
26. DPYS Sensitivity to 5-FU (41,137)
27. ENDRB Endothelin receptor type B (5,41)
28. CADM2 Cell adhesion molecule (138)
29. XAF1 Interference with caspase inhibition of XIAP (139-141)
30. CRBP1 Cellular retinol binding protein, promotes apoptosis (73,142)
31. FAS (TNFRSF6, APT1, CD95/Apo-1) Induces apoptosis (143)
32. RPRM Inhibits Cdc2-cyclin b1 activity (73,123)
33. GSTM1 Detoxification (82)
34. EPB41L3 Erythrocyte membrane protein band 4.1-like 3 (28)
35. SCTR Gene encoding the secretin receptor (105)
36. SOCS1 Negative regulator of cytokine (73,84)
37. HIC Tumor suppressor (79,81)