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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Bone Miner Res. 2014 May;29(5):1170–1182. doi: 10.1002/jbmr.2125

Fig. 1. Postnatal development of inflammation in homozygous Sh3bp2KI/KI knock-in mice.

Fig. 1

H&E staining of (A) first molar in maxilla and surrounding oral soft tissues, (B) lung, and (C) liver tissue section from wild-type (Sh3bp2+/+) and homozygous knock-in (KI) cherubism mutant mice (Sh3bp2KI/KI). Tissues were harvested at various postnatal ages from P1 (postnatal 1 day) to 7 weeks of age. Arrows indicate inflammatory lesions. Insets are magnifications of the dotted areas. Inflammatory nodular lesions in lung (B) develop at 1 week of age, and inflammatory infiltrates in oral (A) and liver (C) tissues are observed at 2 weeks of age.