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Cut-offs were derived from the maximum sensitivity × specificity in respective receiver operator characteristic curve.
| Biomarker | Fluid | Cut-off (ng/mL) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| Syndecan-1 | Pl. effs | 65.7 | 74.9 | 61.3 | 0.77 | 0.57 |
| Syndecan-1 | Sera | 151.6 | 46.1 | 59.1 | 0.70 | 0.27 |
| Osteopontin | Pl. effs | 2034.0 | 65.5 | 61.1 | 0.60 | 0.65 |
| Osteopontin | Sera | 217.3 | 52.7 | 60.6 | 0.77 | 0.34 |
Pl. effs: pleural effusions; PPV: positive predictive value; NPV: negative predictive value.
