Table 4.
List of quorum quenching bacteria reported to degrade or modify AHLs.
| Quenching bacteria | Gene involved | AHLs degraded | Phenotypes regulated | Reference |
|---|---|---|---|---|
| AHL-acylase mediated QQ | ||||
| Anabaena sp. PCC7120 | aiiC | C4-HSL, 3-oxo-C4-HSL, 3-hydoxo-C4-HSL, 3-oxo-C6-HSL, 3-hydoxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, 3-hydoxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, 3-hydoxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, 3-hydoxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, 3-hydoxo-C14-HSL, and C14-HSL | n.d. | [106] |
|
| ||||
| Acinetobacter sp. strain Ooi24 | Unknown | C10-HSL | n.d. | [89] |
|
| ||||
| B. pumilus S8-07 | Unknown | 3-Oxo-C12-HSL | Inhibit biofilm formation in P. aeruginosa PA01 | [107] |
|
| ||||
| Comamonas strain D1 | Unknown | C4-HSL, 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, C14-HSL, and C16-HSL | Decreases virulence and antibiotic production in Pec. carotovorum strain Pcc797 | [108] |
|
| ||||
| P. aeruginosa | quiP | C6-HSL, C8-HSL, C10-HSL, and C12-HSL | Inhibits biofilm formation in Aeromonassp. | [109] |
|
| ||||
| P. aeruginosa PA01 | PA2385 | 3-Oxo-C12-HSL | Reduce virulence factor elastase and pyocyanin in P. aeruginosa PA01 | [73] |
|
| ||||
| P. syringae strain B728a | hacA | C8-HSL, C10-HSL, and C12-HSL | Influence biofilm formation | [110] |
|
| ||||
| P. syringae strain B728a | hacB | 3-Oxo-C6-HSL, C6-HSL, C8-HSL, C10-HSL, 3-oxo-C12-HSL, and C12-HSL | Influence biofilm formation | [110] |
|
| ||||
| P. aeruginosa PAO1 | PA2385 | C11-HSL, 3-oxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, and C14-HSL | Decreases elastolytic activity and pyocyanin production | [73] |
|
| ||||
| Pseudomonas sp. strain PAI-A | pvdQ | C10-HSL, 3-oxo-C12-HSL, C12-HSL, and C14-HSL | Inhibit virulence factor | [111] |
|
| ||||
| P. aeruginosa PAO1 | quiP | C8-HSL, C10-HSL, 3-oxo-C12-HSL, and C12-HSL | Inhibit virulence factor | [112] |
|
| ||||
| Pseudomonas sp. 1A1 | Unknown | C6-HSL, C8-HSL, 3-oxo-C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, and C12-HSL | Inhibit biofilm formation in MBR | [113] |
|
| ||||
| Rho. erythropolis strain W2 | Unknown | C4-HSL, 3-oxo-C6-HSL, C6-HSL, C7-HSL, 3-oxo-C8-HSL, C8-HSL, and C10-HSL | Reduces pathogenicity of Pec. carotovorum subsp. carotovorum in plants | [114, 115] |
|
| ||||
| Ralstonia sp. XJ12B | aiiD | 3-Oxo-C8-HSL, 3-oxo-C10-HSL, and 3-oxo-C12-HSL | Decreases swarming ability and production of elastase and pyocyanin in P. aeruginosa PA01 | [20] |
|
| ||||
| Ralstonia solanacearum GMI1000 | aac | C7-HSL, C8-HSL, 3-oxo-C8-HSL, and C10-HSL | Inhibits violacein and chitinase activity in C. violaceum CV026 | [116] |
|
| ||||
| Streptomyces sp. strain M664 | ahlM | C8-HSL, C10-HSL, and 3-oxo-C12-HSL | Decreases virulence factor, elastase, protease, and LasA in P. aeruginosa | [117] |
|
| ||||
| Shewanella sp. strain MIB015 | aac | C8-HSL, C10-HSL, and C12-HSL | Reduces biofilm formation in V. anguillarum | [118] |
|
| ||||
| Variovorax paradoxus strain VAI-C | Unknown | C4-HSL, 3-oxo-C6-HSL, C6-HSL, C8-HSL, C10-HSL, and C12-HSL | n.d. | [119] |
|
| ||||
| AHL-lactonase mediated QQ | ||||
| Ag. tumefaciens c58 | attM | 3-Oxo-C8-HSL | Inhibit Ti plasmid conjugal transfer | [120] |
|
| ||||
| Ag. tumefaciens | aiiB | C4-HSL, 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, and C10-HSL | n.d. | [121] |
|
| ||||
| Ag. tumefaciens C58 | aiiB | 3-Oxo-C6-HSL, C6-HSL, C8-HSL, C7-HSL, 3-oxo-C8-HSL, and C8-HSL | Reduces virulence of Erwinia strain 6276 | [122] |
|
| ||||
| Ag. tumefaciens K84 | aiiS | 3-Oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, and C14-HSL |
n.d. | [123, 124] |
|
| ||||
| Acinetobacter sp. strain C1010 | Unknown | C6-HSL, C8-HSL | Inhibit production of phenazines in P. chlororaphis O6 and virulence in Er. carotovora | [125] |
|
| ||||
| Acinetobacter sp. GG2 | Unknown | 3-Hydroxy-C4-HSL, C5-HSL, 3-hydroxy-C6-HSL, C6-HSL, C7-HSL, 3-oxo-C8-HSL, 3-hydroxy-C8-HSL, C8-HSL, C9-HSL, and 3-oxo-C10-HSL, 3-hydroxy-C10-HSL, C10-HSL, C11-HSL, 3-oxo-C12-HSL, 3-hydroxy-C12-HSL, C12-HSL, 3-oxo-C14-HSL, 3-hydroxy-C14-HSL, C14-HSL, Δ9-3-hydroxy-C14-HSL, Δ10-3-hydroxy-C14-HSL, Δ11-3-hydroxy-C14-HSL, and Δ13-3-hydroxy-C14-HSL | Attenuates virulence of P. aeruginosa and Er. carotovora | [109] |
|
| ||||
| Acidobacteria sp. | qIcA | 3-Oxo-C6-HSL, C6-HSL, C7-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, and C10-HSL | Decreases virulence of Pec. carotovorum strain 6276 | [126] |
|
| ||||
| Arthrobacter sp. IBN110 | ahlD | C4-HSL, 3-oxo-C6-HSL, C6-HSL, C8-HSL, 3-oxo-C10-HSL, and C10-HSL | Decreases virulence of Er. carotovora N98 | [127] |
|
| ||||
| Bacillus sp. 240B1 | aiiA | C8-HSL | Decreases extracellular pectolytic enzyme activities and inhibits virulence in Er. carotovora | [128, 129] |
|
| ||||
| B. cereus | aiiA | C6-HSL, C8-HSL, and C10-HSL | Decreases virulence factor | [130] |
|
| ||||
| B. mycoides | aiiA | C6-HSL, C8-HSL, and C10-HSL | Decreases virulence factor | [130] |
|
| ||||
| Bacillus strain COT1 | aiiA | 3-Oxo-C6-HSL | Decreases virulence factor | [130] |
|
| ||||
| B. anthracis | aiiA | C6-HSL, C8-HSL, and C10-HSL | Decreases swarming in Bur. thailandensis | [131] |
|
| ||||
| B. pumilus SW9 | Unknown | n.d. | Inhibit biofouling on microfiltration membranes by Brevundimonas sp. SW1, Acidovorax sp. DB3, Acinetobacter sp. GS1, and Staphylococcus aureus SA1 | [132, 133] |
|
| ||||
| B. thuringiensis subspecies morrisoni | aiiA | 3-Oxo-C6-HSL | Attenuates the pathogenicity of Er. carotovora | [134] |
|
| ||||
| B. thuringiensis | aiiA | 3-Oxo-C6-HSL | Decreases virulence of Er. carotovora | [135] |
|
| ||||
| Bacillus sp. A24 | aiiA | C4-HSL, C6-HSL | Decreases production of elastase, rhamnolipids, and pyocyanin and inhibits swarming in P. aeruginosa PA01 | [136] |
|
| ||||
| En. asburiae VT65 | aiiA | C4-HSL, C6-HSL | n.d. | [137] |
|
| ||||
| Geobacillus kaustophilus strain HTA426 | GKL | C4-HSL, 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, C10-HSL, and 3-oxo-C12-HSL | Thermostable antivirulence therapeutic agent | [138] |
|
| ||||
| K. pneumonia | ahlK | C6-HSL, 3-oxo-C6-HSL | Decreases virulence of Er. carotovora N98 | [127] |
|
| ||||
| M. testaceum StLB018 | Unknown | C6-HSL, 3-oxo-C6-HSL, C10-HSL, and 3-oxo-C10-HSL | Interrupts pathogenicity of Pec. carotovorum subsp. carotovorum | [139] |
|
| ||||
| Mycobacterium avium subsp. paratuberculosis K-10 | MCP | C7-HSL, C8-HSL, 3-oxo-C8-HSL, C10-HSL, and C12-HSL | n.d. | [140] |
|
| ||||
| My. tuberculosis | AhlA, PPH | C4-HSL, 3-oxo-C8-HSL, and C10-HSL | n.d. | [141] |
|
| ||||
| M. testaceum StLB037 | aiiM | 3-Oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, and C10-HSL |
Reduces pectinase activity and virulence in Pec. carotovorum subsp. carotovorum | [142] |
|
| ||||
| Ochrobactrum sp. T63 | aidH | C4-HSL, C6-HSL, 3-oxo-C6-HSL, 3-oxo-C8-HSL, and C10-HSL | Reduce biofilm formation by P. fluorescens 2P24 and the pathogenicity of Pec. carotovorum | [143] |
|
| ||||
| Pichia pastoris | aiiA B546 | 3-Oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, C10-HSL, and C12-HSL | Attenuates the A. hydrophila infection in aquaculture | [144] |
|
| ||||
| Pseudoalteromonas byunsanensis strain 1A01261 | qsdH | C4-HSL, 3-oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, C10-HSL, C12-HSL, and C14-HSL | Attenuates the plant pathogenicity of Er. carotovora | [145] |
|
| ||||
| Rho. erythropolis W2 | qsdA | 3-Oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, C12-HSL, 3-oxo-C14-HSL, and C14-HSL |
Decreases virulence of Pec. carotovorum strain PCC797 | [146] |
|
| ||||
| Rhodococcus strain LS31 | Unknown | C6-HSL, 3-oxo-C6-HSL, C10-HSL, and 3-oxo-C10-HSL | Reduces pectate lyase activity in Er. carotovora | [147] |
|
| ||||
| Rhodococcus strain PI33 | Unknown | C6-HSL, C10-HSL | Reduces pectate lyase activity in Er. carotovora | [147] |
|
| ||||
| Rhodococcus sp. BH4 | qsdA | 3-Oxo-C6-HSL, C6-HSL, 3-oxo-C8-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, 3-oxo-C12-HSL, and C12-HSL | Inhibit biofilm formation in MBR | [148, 149] |
|
| ||||
| Rhodococcus sp. A167 | Unknown | C6-HSL, 3-oxo-C8-HSL, and C8-HSL | Attenuates maceration ability of Pec. carotovorum subsp. carotovorum | [150] |
|
| ||||
| Solibacillus silvestris StLB046 | ahlS | C10-HSL | Attenuates maceration of plant pathogen Pec. carotovorum subsp. carotovorum | [151] |
|
| ||||
| Thalassomonas sp. PP2-459 | Unknown | C4-HSL, C6-HSL, C8-HSL, 3-oxo-C10-HSL, C10-HSL, and C12-HSL | Decreases pathogenicity of V. anguillarum ATCC 19264 | [152] |
|
| ||||
| Oxidoreductase mediated QQ | ||||
| B. megaterium CYP102A1 | P450BM3 | Oxidizes; C12-HSL, 3-oxo-C12-HSL, C14-HSL, 3-oxo-C14-HSL, C16-HSL, C18-HSL, and C20-HSL. | n.d. | [153] |
|
| ||||
| Rho. erythropolis W2 | Unknown | Oxidizes; 3-oxo-C10, 3-oxo-C12-HSL | n.d. | [115] |
n.d.: not determined.