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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: Cell. 2013 Sep 26;155(1):200–214. doi: 10.1016/j.cell.2013.08.054

Figure 1.

Figure 1

Improved glucose metabolism and insulin sensitivity of MNKO mice. (A) Shown (top to bottom) are wild-type, floxed, and deleted NCoR gene loci. (B) Relative messenger RNA levels of NCoR in macrophages. Values are fold induction of gene expression normalized to the housekeeping gene 36B4 and expressed as mean ± s.e.m. (C) Body weight of WT and KO mice on 60% HFD. (D) Epi-WAT mass. (E) Fasting blood insulin levels. (F) Fasting FFA levels. (G) Glucose tolerance tests. (H) Glucose infusion rate (GIR) during hyperinsulinmic euglycemic clamp. (I) Glucose disposal rate (GDR). (J) Insulin-stimulated glucose disposal rate (IS-GDR). (K) Percent suppression of HGP by insulin (HGP suppression). (L) Percent suppression of free fatty acid levels (FFA suppression). Values are expressed as mean ± s.e.m. * P<0.05, ** P<0.01 for KO versus WT, or for comparisons as indicated.