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. Author manuscript; available in PMC: 2015 Apr 28.
Published in final edited form as: J Mater Chem B. 2014 Mar 4;2(16):2248–2258. doi: 10.1039/C4TB00125G

Figure 7.

Figure 7

Proposed mechanism of action for MnTBAP composite surfaces. Left: For an unmodified electrode, microglia cells adhere to the surface of the device and release high amounts of reactive oxygen species (ROS). Right: In the presence of our MnTBAP composite surfaces, three possible mechanisms of action could result in decreases in localized ROS released from activated microglia. (A) Immobilized MnTBAP could directly convert extracellular ROS to water. (B) Microglia can internalize released MnTBAP, which could directly decrease the amount of intracellular ROS accumulation. (C) Non-internalized released MnTBAP freely diffuses into the tissue space and can neutralize ROS in the extracellular space.