Table 1.

Circadian analysis of Period1-luciferase (Per1-luc) bioluminescence rhythms of individual cells in Per1 and Per2 wild-type (WT) control and Per1/2-null suprachiasmatic nucleus (SCN) slices, the latter with WT, heterozygous, or homozygous Tau backgrounds. The mean value is the mean of the individual slice values (n). For each individual slice, a large number (ca. >150) of cells was analyzed. *p < 0.05; **p < 0.01 versus control slices; Tukey multiple-comparison test.

	WT controls (n = 3)	Per-null Tau WT (n = 6)	Per-null Tau het (n = 3)	Per-null Tau homo (n = 3)	p value (ANOVA)
Fast Fourier transform pass rate, % + standard error of the mean (SEM)	96.0 + 2.6	34.1 + 5.6**	32.1 + 9.6**	45.0 + 18.0*	<0.01
Period, h + SEM	24.7 + 0.2	27.5 + 1.0	25.5 + 1.4	25.5 + 1.3	0.30; n.s.
Period variance + SEM	2.0 + 0.8	23.5 + 4.1*	20.5 + 1.1	34.1 + 14.9*	0.03
Relative amplitude error	0.18 + 0.07	0.67 + 0.04**	0.70 + 0.03**	0.63 + 0.05**	<0.01
Amplitude	13.4 + 6.1	2.3 + 0.9*	2.5 + 0.6	4.3 + 1.3	0.04
Rayleigh mean vector + SEM	0.92 + 0.02	0.16 + 0.05**	0.31 + 0.15*	0.20 + 0.07**	<0.01
Rayleigh p value (mean)	1*E−12	0.4108	0.1636	0.2497