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. Author manuscript; available in PMC: 2014 Aug 14.
Published in final edited form as: Hypertension. 2012 Aug 6;60(3):712–721. doi: 10.1161/HYPERTENSIONAHA.112.191817

Figure 2. Antagonism of C3aR activation attenuates PE-IgG-induced hypertension and proteinuria in pregnant mice.

Figure 2

Pregnant mice were injected with NT-IgG or PE-IgG with or without infusion of SB290157, a C3aR antagonist. (A) PE-IgG injection resulted in hypertension in pregnant mice and SB290157 significantly reduced hypertension seen in these mice. (B) PE-IgG induced proteinuria in pregnant mice and SB290157 significantly attenuated proteinuria (n=3–5). * P < 0.05 compared to NT-IgG injected mice; ** P < 0.05 compared to PE-IgG injected mice.