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. Author manuscript; available in PMC: 2014 Aug 14.
Published in final edited form as: J Clin Cell Immunol. 2014 Feb;5(1):188. doi: 10.4172/2155-9899.1000188

Figure 11.

Figure 11

Percent of the retinal area covered by astrocytes is a viable index for glaucoma-induced changes in astrocyte microdomains. (A) Quantification of the percent of retinal area covered by astrocytes in 200 mm×200 mm microdomains, represented as % GFAP coverage (y-axis) reveals that normal aging induces a substantial decrease in astrocyte coverage, as compared to young C57 and young DBA/2 retina. In contrast, glaucomatous retina (aged DBA/2) demonstrates a greater than 3-fold increase in astrocyte coverage than its age-matched C57 control. Error bars represent ± standard deviation and asterisks indicate p<0.05. (B) Quantification of total GFAP labeling intensity (arbitrary units; y-axis) reveals that there is no significant difference in overall GFAP expression between conditions. Error bars represent ± standard deviation and asterisks indicate p<0.05.