The reference group for all analyses includes non-runners. All hazard ratios were adjusted for baseline age (years), sex (not in sex-stratified analyses), examination year, smoking status (never, former, or current [not in smoking-stratified analyses]), alcohol consumption (heavy drinker or not [not in alcohol drinking-stratified analyses]), other physical activities except running (0, 1-499, or ≥500 MET-minutes per week), and parental cardiovascular disease (yes or no). Unhealthy was defined as the presence of one or more of the following health conditions: abnormal ECG, hypertension, diabetes, or hypercholesterolemia. Heavy alcohol drinking was defined as >14 and >7 drinks per week for men and women, respectively.
BMI=body mass index, CI=confidence interval, ECG=electrocardiogram.