Table II.

Summary of the top five most significant networks and pathways inferred by IPA.

Network functions	IPA score	Number of genes found
Cancer, cell morphology, cell-to-cell signaling and interaction	43	33
Cell death and survival, inflammatory response, cellular development	32	28
Gene expression, cellular function and maintenance, developmental disorder	32	28
Cell cycle, embryonic development, cellular assembly and organization	30	27
Cell cycle, cancer, hematological disease	25	24

Significant genes were determined by significant methylation differences in the promoters of genes. Summed beta values of the probes in the TSS200 region of promoters were used for the Wilcoxon ranked test at the transcript level. A gene was defined significantly methylated if P < 0.05 after Bonferroni correction. IPA scores are negative log P-values, and higher IPA scores indicate more significance.