Table III.
List of genes of interest involved in pre-eclampsia with DM promoters.
| Gene name | Refseq ID | Promoter (TSS200) |
Body (first exon and body) |
Long gene name | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean control | Mean EOPE | Delta beta | Fold change | Number of probes in TSS200 | Adjusted P-value | Mean control | Mean EOPE | Absolute delta beta | Relative fold change | Number of probes in body | Adjusted P-value | Location in cell | |||
| ARF1 | NM_001658 | 0.07 | 0.04 | 0.03 | −1.98 | 3 | 0.01 | 0.07 | 0.05 | 0.02 | 0.72 | 2 | 0.10 | Cytoplasm | ADP-ribosylation factor 1 |
| PAPPA2 | NM_020318 | 0.11 | 0.26 | 0.15 | 2.28 | 1 | 0.00 | 4.06 | 4.74 | 0.68 | 1.17 | 7 | 0.00 | Extracellular space | Pappalysin 2 |
| IL1RAP | NM_001167928 | 0.13 | 0.03 | 0.09 | −3.90 | 4 | 0.02 | 3.78 | 4.05 | 0.27 | 1.07 | 6 | 0.01 | Plasma membrane | Interleukin 1 receptor accessory protein |
| NRAS | NM_002524 | 0.13 | 0.08 | 0.05 | −1.67 | 1 | 0.00 | 0.02 | 0.01 | 0.01 | 0.60 | 2 | 0.04 | Plasma membrane | Neuroblastoma RAS viral (v-ras) oncogene homolog |
| GRB2 | NM_203506 | 0.16 | 0.09 | 0.08 | −1.88 | 6 | 0.00 | 9.92 | 10.29 | 0.38 | 1.04 | 13 | 0.03 | Cytoplasm | Growth factor receptor-bound protein 2 |
| PSMA1 | NM_148976 | 0.17 | 0.06 | 0.11 | −2.69 | 3 | 0.03 | 4.01 | 4.45 | 0.44 | 1.11 | 23 | 0.00 | Cytoplasm | Proteasome (prosome, macropain) subunit, alpha type, 1 |
| REL | NM_002908 | 0.18 | 0.08 | 0.10 | −2.20 | 3 | 0.03 | 0.07 | 0.03 | 0.04 | 0.48 | 1 | 0.00 | Nucleus | v-rel reticuloendotheliosis viral oncogene homolog (avian) |
| PIK3R3 | NM_001114172 | 0.20 | 0.07 | 0.13 | −2.88 | 4 | 0.04 | 2.23 | 2.52 | 0.29 | 1.13 | 7 | 0.00 | Cytoplasm | Phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| GNGT1 | NM_021955 | 0.21 | 0.44 | 0.24 | 2.14 | 1 | 0.00 | NA | NA | NA | NA | 0 | NA | Plasma Membrane | Guanine nucleotide-binding protein (G protein), gamma transducing activity polypeptide 1 |
| PSMD1 | NM_002807 | 0.22 | 0.09 | 0.13 | −2.46 | 4 | 0.01 | 5.28 | 5.96 | 0.69 | 1.13 | 11 | 0.00 | Cytoplasm | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 |
| DIDO1 | NM_033081 | 0.22 | 0.07 | 0.15 | −3.04 | 3 | 0.01 | 7.45 | 8.01 | 0.56 | 1.08 | 11 | 0.00 | Nucleus | Death inducer-obliterator 1 |
| NFKBIA | NM_020529 | 0.23 | 0.10 | 0.13 | −2.31 | 4 | 0.03 | 0.58 | 0.66 | 0.08 | 1.14 | 8 | 0.37 | Cytoplasm | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NFKB2 | NM_001077493 | 0.25 | 0.13 | 0.12 | −1.90 | 6 | 0.04 | 0.31 | 0.28 | 0.04 | 0.89 | 6 | 0.97 | Nucleus | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| CFHR5 | NM_030787 | 0.26 | 0.49 | 0.23 | 1.91 | 1 | 0.00 | 0.69 | 0.69 | 0.00 | 1.00 | 1 | 0.94 | Extracellular Space | Complement factor H-related 5 |
| ANXA2 | NM_004039 | 0.27 | 0.15 | 0.12 | −1.76 | 5 | 0.03 | 2.60 | 2.94 | 0.34 | 1.13 | 5 | 0.01 | Plasma membrane | Annexin A2 |
| HNF4G | NM_004133 | 0.27 | 0.52 | 0.25 | 1.94 | 1 | 0.01 | NA | NA | NA | NA | 0 | NA | Nucleus | Hepatocyte nuclear factor 4, gamma |
| IL12B | NM_002187 | 0.27 | 0.55 | 0.28 | 2.03 | 1 | 0.00 | 1.17 | 1.36 | 0.18 | 1.16 | 3 | 0.05 | Extracellular Space | Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
| ATF3 | NM_001040619 | 0.27 | 0.07 | 0.20 | −3.90 | 2 | 0.00 | 0.04 | 0.04 | 0.01 | 0.87 | 2 | 0.34 | Nucleus | Activating transcription factor 3 |
| GFI1B | NM_004188 | 0.28 | 0.54 | 0.26 | 1.92 | 1 | 0.02 | 3.15 | 3.51 | 0.37 | 1.12 | 4 | 0.00 | Nucleus | Growth factor independent 1B transcription repressor |
| PSME1 | NM_006263 | 0.28 | 0.12 | 0.16 | −2.33 | 5 | 0.02 | 0.27 | 0.19 | 0.08 | 0.71 | 4 | 0.05 | Cytoplasm | Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| SPINK7 | NM_032566 | 0.29 | 0.56 | 0.27 | 1.95 | 1 | 0.01 | 1.27 | 1.43 | 0.16 | 1.12 | 2 | 0.28 | Extracellular Space | Serine peptidase inhibitor, Kazal type 7 (putative) |
| GABRA1 | NM_001127647 | 0.30 | 0.59 | 0.29 | 1.98 | 1 | 0.00 | NA | NA | NA | NA | 0 | NA | Plasma Membrane | Gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
| RASA2 | NM_006506 | 0.32 | 0.12 | 0.19 | −2.58 | 2 | 0.00 | 3.29 | 3.93 | 0.64 | 1.19 | 10 | 0.00 | Cytoplasm | RAS p21 protein activator 2 |
| CCL20 | NM_004591 | 0.36 | 0.68 | 0.32 | 1.90 | 1 | 0.00 | 1.75 | 1.85 | 0.10 | 1.06 | 2 | 0.36 | Extracellular Space | Chemokine (C-C motif) ligand 20 |
| mir-185 | NR_029968 | 0.41 | 0.64 | 0.23 | 1.55 | 2 | 0.04 | NA | NA | NA | NA | 0 | NA | Cytoplasm | mir-185 |
| PIK3R4 | NM_014602 | 0.44 | 0.16 | 0.28 | −2.75 | 2 | 0.02 | 1.82 | 1.94 | 0.12 | 1.07 | 7 | 0.00 | Cytoplasm | Phosphoinositide-3-kinase, regulatory subunit 4 |
| PSMD8 | NM_002812 | 0.51 | 0.23 | 0.28 | −2.24 | 6 | 0.03 | 1.51 | 1.62 | 0.11 | 1.07 | 7 | 0.02 | Cytoplasm | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 |
| mir-519a1 | NR_030218 | 0.58 | 0.88 | 0.30 | 1.51 | 2 | 0.00 | NA | NA | NA | NA | 0 | NA | Cytoplasm | mir-519a1 |
| POPDC2 | NM_022135 | 0.64 | 1.25 | 0.61 | 1.96 | 2 | 0.00 | 2.37 | 2.59 | 0.21 | 1.09 | 3 | 0.01 | Plasma Membrane | Popeye domain containing 2 |
| mir-301a | NR_029842 | 0.78 | 0.92 | 0.14 | 1.18 | 2 | 0.02 | 0.87 | 0.91 | 0.04 | 1.04 | 1 | 0.50 | Cytoplasm | mir-301a |
| RBCK1 | NM_006462 | 0.80 | 0.48 | 0.31 | −1.64 | 6 | 0.03 | 5.12 | 5.33 | 0.22 | 1.04 | 7 | 0.01 | Cytoplasm | RanBP-type and C3HC4-type zinc finger containing 1 |
| mir-329-2 | NR_029706 | 1.30 | 1.66 | 0.36 | 1.28 | 4 | 0.02 | NA | NA | NA | NA | 0 | NA | Cytoplasm | mir-329-2 |
| mir-487a | NR_030162 | 1.50 | 1.73 | 0.24 | 1.16 | 4 | 0.04 | 0.91 | 0.93 | 0.02 | 1.02 | 1 | 0.37 | Cytoplasm | mir-487a |
| IL3 | NM_000588 | 2.23 | 2.68 | 0.44 | 1.20 | 3 | 0.04 | 0.81 | 0.94 | 0.13 | 1.17 | 1 | 0.00 | Extracellular Space | Interleukin 3 (colony-stimulating factor, multiple) |
| UTRN | NM_007124 | 2.66 | 2.82 | 0.17 | 1.06 | 3 | 0.03 | 24.26 | 25.87 | 1.61 | 1.07 | 31 | 0.00 | Plasma Membrane | Utrophin |
| SUMO4 | NM_001002255 | 4.41 | 4.80 | 0.39 | 1.09 | 5 | 0.00 | 0.88 | 0.95 | 0.07 | 1.09 | 1 | 0.00 | Cytoplasm | Small ubiquitin-like modifier 4 |