Fig. 2. : diagram of genes that have been implicated in susceptibility to cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) disease caused by Leishmania braziliensis in the area of Corte de Pedra, state of Bahia, Brazil, showing involvement of, and interaction with, the transforming growth factor β (TGFβ) pathway. Polymorphisms in genes annotated in red lettering have been associated with CL or ML disease. Turquoise circles indicate the pathway through which interleukin (IL)-6 influences SMAD4 via FLI1. SP1/3 are transcription factors that influence FLI1 expression. CTGF: connective tissue growth factor. Source: Castellucci et al. (2012).