In the dose range studied, scopolamine administration reduced heart rate and blood pressure, putatively reflecting enhancement of the central parasympathetic autonomic outflow (50–52). (A) Mean heart rate (± SE) is shown for the placebo (blue) and the scopolamine (red) sessions averaged over all subjects. Bars reflect baseline, as well as heart rate, at each time point indicated, relative to infusion start time. (B) Mean systolic blood pressure (± SE) is shown for the placebo (blue) and the scopolamine (red) sessions averaged over all subjects. Bars reflect baseline, as well as systolic pressure, at each time point indicated, relative to infusion start time. (C) Diastolic blood pressure (± SE) is shown for the placebo (blue) and the scopolamine (red) sessions averaged over all subjects. Bars reflect baseline, as well as diastolic pressure, at each time point indicated, relative to infusion start time.