Table 3.
Multivariable Cox Proportional Hazards Regression Model of 1-Year Mortality
| Variable | Hazard Ratio | 95% Confidence Interval |
P-Value |
|---|---|---|---|
| Acuity | |||
| Highest LAS Quartile | 1 (Reference) | -- | |
| Ventilator Support | 1.99 | [1.59-2.50] | <0.001 |
| ECMO Support | 3.03 | [2.00-4.59] | <0.001 |
| Recipient Variables | |||
| Age > 60 years | 1.23 | [0.97-1.55] | 0.1 |
| Total bilirubin (per mg/dL) | 1.07 | [1.04-1.10] | <0.001 |
| GFR > 90 | 1 (Reference) | -- | |
| GFR 60-90 | 1.29 | [1.03-1.61] | 0.02 |
| GFR < 60 | 1.55 | [1.16-2.07] | 0.003 |
| FEV1 (per % predicted) | 1.01 | [0.99-1.01] | 0.1 |
| Inhaled NO | 1.74 | [0.97-3.11] | 0.1 |
| COPD | 1 (Reference) | -- | |
| IPF | 0.86 | [0.57-1.28] | 0.4 |
| CF | 0.94 | [0.58-1.53] | 0.8 |
| PPHN | 0.60 | [0.18-2.04] | 0.4 |
| Other diagnosis | 1.01 | [0.67-1.54] | 0.9 |
| Donor Variables | |||
| Age (per year) | 1.01 | [0.99-1.01] | 0.051 |
| Male gender | 0.94 | [0.77-1.15] | 0.6 |
| Cigarette use | 1.12 | [0.86-1.47] | 0.4 |
| Transplant Variables | |||
| Redo LTx | 1.13 | [0.79-1.63] | 0.5 |
| Bilateral LTx | 0.73 | [0.58-0.94] | 0.01 |
| Ischemic time (per hour) | 1.05 | [0.99-1.13] | 0.5 |
| Same race matching | 0.98 | [0.80-1.19] | 0.8 |
| Transplant year | 0.93 | [0.88-0.99] | 0.02 |
| (per year since LAS) | |||
| Annual Center Volume | |||
| 1-21 LTx/year | 1 (Reference) | -- | |
| 22-35 LTx/year | 0.74 | [0.56-0.98] | 0.04 |
| 36-53 LTx/year | 0.59 | [0.44-0.78] | <0.001 |
| ≥ 54 LTx/year | 0.56 | [0.43-0.73] | <0.001 |
Abbreviations: LAS, lung allocation score; ECMO, extracorporeal membrane oxygenation; GFR, glomerular filtration rate; FEV1, forced expiratory volume in 1 second; NO, nitric oxide; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; CF, cystic fibrosis; PPHN, primary pulmonary hypertension; LTx, lung transplantation.