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. Author manuscript; available in PMC: 2014 Aug 14.
Published in final edited form as: J Heart Lung Transplant. 2012 Aug 11;31(11):1182–1191. doi: 10.1016/j.healun.2012.07.001

Table 3.

Multivariable Cox Proportional Hazards Regression Model of 1-Year Mortality

Variable Hazard Ratio 95% Confidence
Interval
P-Value
Acuity
Highest LAS Quartile 1 (Reference) --
Ventilator Support 1.99 [1.59-2.50] <0.001
ECMO Support 3.03 [2.00-4.59] <0.001
Recipient Variables
Age > 60 years 1.23 [0.97-1.55] 0.1
Total bilirubin (per mg/dL) 1.07 [1.04-1.10] <0.001
GFR > 90 1 (Reference) --
GFR 60-90 1.29 [1.03-1.61] 0.02
GFR < 60 1.55 [1.16-2.07] 0.003
FEV1 (per % predicted) 1.01 [0.99-1.01] 0.1
Inhaled NO 1.74 [0.97-3.11] 0.1
COPD 1 (Reference) --
IPF 0.86 [0.57-1.28] 0.4
CF 0.94 [0.58-1.53] 0.8
PPHN 0.60 [0.18-2.04] 0.4
Other diagnosis 1.01 [0.67-1.54] 0.9
Donor Variables
Age (per year) 1.01 [0.99-1.01] 0.051
Male gender 0.94 [0.77-1.15] 0.6
Cigarette use 1.12 [0.86-1.47] 0.4
Transplant Variables
Redo LTx 1.13 [0.79-1.63] 0.5
Bilateral LTx 0.73 [0.58-0.94] 0.01
Ischemic time (per hour) 1.05 [0.99-1.13] 0.5
Same race matching 0.98 [0.80-1.19] 0.8
Transplant year 0.93 [0.88-0.99] 0.02
(per year since LAS)
Annual Center Volume
1-21 LTx/year 1 (Reference) --
22-35 LTx/year 0.74 [0.56-0.98] 0.04
36-53 LTx/year 0.59 [0.44-0.78] <0.001
≥ 54 LTx/year 0.56 [0.43-0.73] <0.001

Abbreviations: LAS, lung allocation score; ECMO, extracorporeal membrane oxygenation; GFR, glomerular filtration rate; FEV1, forced expiratory volume in 1 second; NO, nitric oxide; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; CF, cystic fibrosis; PPHN, primary pulmonary hypertension; LTx, lung transplantation.