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. 2014 Aug 13;9(8):e102709. doi: 10.1371/journal.pone.0102709

Figure 5. Anti-tumor effects of IT in CD4 knockout mice.

Figure 5

3LL tumor bearing WT or CD4 knockout (B6.129S2-CD4tm1Mak/J) mice were treated with IT or PBS/rIgG (control) and survival and tumor growth were measured. For in vivo tumor studies one million 3LL cells were administered by s.c. injection into the flank of C57BL/6 mice seven days prior to initiation of therapy. (a) Survival. (b) Mean tumor volume with SEM. (c–f) Growth plots of individual tumors in each group. N = 12 mice per group. (*P<.05, **P<.01, ***P<.001).