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. 2014 Aug 13;9(8):e104546. doi: 10.1371/journal.pone.0104546

Figure 6. Injection of TRPV1 antagonist CPZ in unilateral of NAc or DS did not change persistent mCPP expression after short-term(1 w) withdrawal.

Figure 6

(A) Unilateral NAc CPZ injection (10 nM) or one side off-target during bilateral NAc CPZ infusion (1 nM or 10 nM) failed to affect the sustained mCPP. The upper panel shows the scheme for morphine conditioning, CPZ treatment and mCPP test. Values are Mean ±SEM (n = 7 of Vehicle and Uni-NAc+CPZ group and n = 3 of Uni-off NAc+CPZ group). (B) CPZ (10 nM) injection in DS failed to influence persistent morphine CPP. The upper panel shows rats were conditioned to morphine and received CPZ injections in bilateral DS after short-term withdrawal. Values are mean ±SEM (n = 6 of DS-Vehicle group and n = 7 of DS-CPZ 10 nM group). MOR, morphine; Veh, vehicle; CPZ, capsazepine; NAc, nucleus accumbens; Uni, unilateral; DS, dorsal striatum.