Table 4.
Effects of CPAP treatment duration, efficacy, and baseline BMI on hyperleptinemia.
| Study | Sample size and treatment duration |
Pre-BMI (kg/m2) | Post-BMI (kg/m2) | Pre-AHI (event/h) | Post-AHI (event/h) | Leptin concentration |
|---|---|---|---|---|---|---|
| Barcelo 2005 [51] | 4 groups of 18–24/group, 3 or 12 m |
25.9 in non-obese and 34.9 in obese groups |
nd | 43 in non-obese and 49 in obese groups |
nd | ↓ |
| Cuhadaroglu 2009 [55] | 31 patients, 8 wk | 32 | nd | 43 | Nd | ↓ |
| Drummond 2008 [62] | 98 patients, 1 wk and 6 m | 33.2 | nd | 51.7 | 2.7 ± 1.7 | No change |
| Garcia 2011 [63] | 20 patients × 6 m | 36.5 | 37.1 | >15 | Not specified | No change |
| Harsch 2003 [54] | 30 men, 8 wk | 32.6 | nd | 58 ± 16 | nd | ↓ |
| Huang 2004 [60] | 8 patients, 1 d and 7.5 m | nd | nd | nd | nd | ↓ |
| Nakra 2008 [57] | 25 children with OSA and 9 without |
z score of 2.8 with OSA and z score of 2.57 without |
No change | 8.68 | nd | ↓ by CPAP |
| Rubinsztajn 2006 [61] | 29 men, 3 wk | nd | nd | nd | nd | No change |
| Sanchez-de-la-Torre 2011 [49] | 28 obese men and 21 non-obese men, 3 m |
>30 as obese and <27 as control |
nd | >20 | ↓ | |
| Sanner 2004 [59] | 53 patient, 6 m | nd | nd | 29.4 | 1.6 | ↓ |
| Sanner 2004 [59] | 26 patient, 6 m, ineffectively treated |
nd | nd | 24.8 | 13.7 | ↑ |
| Trenell 2007 [56] | 19 patients > 3 m | 36 | nd | 64 | nd | ↓ |
| Yee 2006 [53] | 14 patients, 1.6–3 y | 40.9 | nd | 44 (RDI) | nd | ↓ |
nd: no data.