Table 4.

Subgroup analyses of the association of BNP to AF risk adjusted for age, gender and race

Subgroup	Hazard Ratio per standard deviation of log(BNP)	95% Confidence Interval	p-value	Interaction p-value
Age				<0.01*
65–69	1.93	1.69–2.21	<0.00001
70–74	1.81	1.60–2.05	<0.00001
75–79	1.75	1.51–2.02	<0.00001
80–84	1.61	1.31–1.97	<0.0001
85–100	1.55	1.07–2.25	<0.05
Gender				n.s.
Female	1.88	1.70–2.08	<0.00001
Male	1.66	1.51–1.83	<0.00001
African-American				n.s.
No	1.77	1.64–1.91	<0.00001
Yes	1.75	1.46–2.10	<0.00001
Prevalent CVD				<0.01
No	1.53	1.35–1.74	<0.00001
Yes	1.80	1.65–1.97	<0.00001
Hypertension				n.s.
No	1.73	1.56–1.92	<0.00001
Yes	1.75	1.59–1.94	<0.00001
Overweight or obese (BMI>25)				n.s.
No	1.73	1.54–1.95	<0.00001
Yes	1.83	1.67–2.01	<0.00001
Left Atrial Dimension †				n.s.
1st Quintile	1.64	1.36–1.99	<0.00001
2nd Quintile	1.96	1.62–2.38	<0.00001
3rd Quintile	1.59	1.33–1.89	<0.00001
4th Quintile	1.91	1.62–2.26	<0.00001
5th Quintile	1.61	1.40–1.85	<0.00001

^*Test for linear trend with age as a continuous variable

^†Left Atrial Dimension was only available for the original cohort participants with a NT-BNP measurement at baseline because the echocardiogram was performed two years after enrollment of the minority cohort.