Table 2.
Essentiality of peptidoglycan synthesis genesa
| Gene | C. crescentusb | B. subvibrioides | A. tumefaciens | |||
|---|---|---|---|---|---|---|
| Peptidoglycan precursor synthesis | ||||||
| Gene | Gene | Gene | ||||
| MurA | CC_2350 | E | Bresu_2247 | E | Atu0539 | E |
| MurB | CC_2545 | E | Bresu_2691 | E | Atu2092 | E |
| MurC | CC_2546 | E | Bresu_2692 Bresu_1060 |
E N |
Atu2093 | E |
| MurD | CC_2556 | E | Bresu_2778 | E | Atu2096 | E |
| MurE | CC_2559 | E | Bresu_2781 | E | Atu2099 | E |
| MurF | CC_2558 | E | Bresu_2780 | E | Atu2098 | E |
| MurG | CC_2551 | E | Bresu_2776 | E | Atu2096 | E |
| MraY | CCNA_02640c | E | Bresu_2779 | E | Atu2097 | E |
| Ddl | CC_2543 | E | Bresu_2690 | E | Atu2089 | E |
| Alr | CC_1661 | N | Bresu_1809 | N | Atu1080 Atu3292 |
N N |
| MurI | CC_3703 | U | Bresu_0665 | E | Atu1867 | N |
| Cell wall polymerization | ||||||
| PBP1a | CC_1875 CC_0252 CC_1516 CC_3277 |
N U N N |
Bresu_2191 Bresu_0560 |
N N |
Atu1341 Atu0103 |
E N |
| PBP1c | CC_3570 | N | NH | - | Atu3694 | N |
| PBP2 | CC_1546 | E | Bresu_2296 | E | NH | - |
| PBP3 | CC_2560 | E | Bresu_2782 | E | Atu2100 | E |
| MtgA | CC_0325 | N | Bresu_1024 | N | Atu2720 | N |
| Unknown multi-PBP | Atu0931 | N | ||||
| Unknown mono-PBP | Atu1067 | N | ||||
a
Designations: E = essential, N = non-essential, U = unresolved/high fitness, NH = no homolog.
b
Essential designations based upon (Christen et al., 2011).
c
Unannotated in the CB15 genome, annotated in the laboratory domesticated NA1000 derivative.