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. 2014 Aug 13;9(8):e105118. doi: 10.1371/journal.pone.0105118

Figure 9. Striatal levels of DA and DOPAC were measured at 8 weeks after grafting with the different rMSCs groups.

Figure 9

Mean DA level in the striatum of PD animals was 91.6% lower than that of control (0.53±0.08 vs. 11.28±0.65 ng/mg brain tissue). There was no significant difference between PD group and vehicle group. After transplantation with engineered rMSCs, the mean striatal DA level in the untransduced MSCs, LV-null-MSCs group and LV-PSPN-MSCs group was higher than that in PD rat, respectively. Furthermore, the DA levels in LV-PSPN-MSCs group was also greater than that in rats treated with MSCs or LV-null-MSCs. Bars indicate mean ± SD. (*P<0.05, compared to the control; # P<0.05, compared to the PD group; ∧ P<0.05, compared to MSCs or LV-null-MSCs group).