Figure 2. Long term adminstration of exendin-4, liraglutide and sitagliptin exerts different effects on beta-cell mass but no effect on alpha-cell mass.

Representative images of pancreatic sections stained for insulin (green), glucagon (red) and nuclei (DAPI, blue) (A). Pancreatic sections from mice treated with liraglutide (B, E), exendin-4 (C, F) and sitagliptin (D, G) were examined. Beta-cell mass (B, C, D), and alpha-cell mass (E, F, G) were measured from whole section scans as described in ‘Materials and Methods’. p≤0.001, ***; p≤0.01, n = 3–7 mice.