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. 2014 Aug 13;9(8):e103168. doi: 10.1371/journal.pone.0103168

Table 1. Baseline characteristics of the patients.

Characteristics Per-protocol set
BF tablet group BY granule group Placebo group P-value
n = 82 n = 89 n = 91
Age(year) 62.43±9.04 61.51±8.79 62.68±8.10 0.5039
Height(cm) 165.22±8.13 164.45±8.97 166.03±8.59 0.285
Weight(Kg) 61.81±9.41 60.89±11.45 64.49±11.81 0.0382
Course of disease(month) 12.57±8.39 12.75±8.95 12.43±9.46 0.9946
Family history 0.92
Yes 19(23.17%) 22(24.72%) 22(24.18%)
No 63(76.83%) 67(75.28%) 69(75.82%)
Smoking history 0.122
Yes 27(32.93%) 41(46.59%) 36(39.56%)
No 55(67.07%) 47(53.41%) 55(60.44%)
Disease history 0.145
Yes 25(30.49%) 18(22.22%) 32(35.96%)
No 57(69.51%) 63(77.78%) 57(64.04%)
Medical history 0.981
Yes 40(48.78%) 42(47.73%) 45(49.45%)
No 42(51.22%) 46(52.27%) 46(50.55%)
Gender 0.333
Male 64(78.05%) 62(69.66%) 69(75.82%)
Female 18(21.95%) 27(30.34%) 22(24.18%)
Blood pressure
Systolic pressure(mm/Hg) 121.84±10.06 122.09±8.10 120.88±9.62 0.6734
Diastolic pressure 77.36±5.58 76.40±6.00 76.40±7.27 0.3923
Respiratory times(per minute) 19.33±2.06 18.89±2.26 18.78±2.09 0.052
Temperature(°C) 36.64±0.27 36.67±0.23 36.67±0.25 0.7375
Heart rate(per minute) 79.43±10.78 76.82±6.82 77.79±8.66 0.1248
Chest radiograph 0.601
Normal 25(32.05%) 22(25.88%) 25(29.41%)
Abnormal 53(67.95%) 63(74.12%) 60(70.59%)
Lung function
VC(L) 2.38±0.84 2.35±0.76 2.44±0.93 0.7528
FEV1(%) 46.65±15.55 48.47±15.44 46.30±15.14 0.5654
FEV1/FVC(%)pre 50.33±11.15 53.77±11.24 50.36±10.83 0.0898
FEV1/FVC(%)post 51.38±10.58 54.65±13.51 51.33±13.76 0.2968
PEF(L/S) 3.30±1.54 3.32±1.48 3.14±1.57 0.854
GOLD Classification by Spirometry 0.674
I(mild) 1(1.22%) 0(0.00%) 2(2.20%)
II(moderate) 34(41.46%) 42(47.19%) 34(37.36%)
III(severe) 45(54.88%) 44(49.44%) 50(54.95%)
IV(very severe) 2(2.44%) 3(3.37%) 5(5.49%)
Differentiation of syndrome of TCM
qi deficiency 0.182
Yes 41(50.00%) 45(50.56%) 55(60.44%)
No 41(50.00%) 44(49.44%) 36(39.56%)
kidney qi deficiency 0.104
Yes 56(68.29%) 57(64.04%) 50(54.95%)
No 26(31.71%) 32(35.96%) 41(45.05%)
kidney yang deficiency 0.35
Yes 17(20.73%) 27(30.34%) 25(27.47%)
No 65(79.27%) 62(69.66%) 66(72.53%)
hyperactivity of fire due to yin
Yes 0(0.00%) 0(0.00%) 0(0.00%)
No 82(100.0%) 89(100.0%) 91(100.0%)

NOTE: There are no significant differences (P>0.05) at the baseline of population (index of population: sex, age, height, weight, course of disease, family history, smoking history, past disease history, past medication history), general physical examination (BP, respiratory times, chest radiograph, temperature, heart rate), syndrome differentiation of TCM, and COPD classification, besides weight (P<0.05 BY group for placebo group).