Table 2. Variable of lung function, Frequency of acute exacerbation, and Score and descent range of SGRQ before and after treatment.
| Variables | Per-protocol set | |||
| BF tablet group | BY granule group | Placebo group | P-value | |
| n = 82 | n = 89 | n = 91 | ||
| Lung function | ||||
| VC(L) | ||||
| Before treatment | 2.38±0.84 | 2.35±0.76 | 2.44±0.93 | 0.7528 |
| After treatment | 2.53±0.61 | 2.42±0.56 | 2.47±0.76 | 0.7077 |
| FEV1(%) (percentage of predicted value) | ||||
| Before treatment | 46.65±15.55 | 48.47±15.44 | 46.30±15.14 | 0.5654 |
| After treatment | 46.91±16.10 | 50.57±16.39 | 46.30±16.92 | 0.2307 |
| FEV1/FVC (%) (pre-bronchodilator) | ||||
| Before treatment | 50.33±11.15 | 53.77±11.24 | 50.36±10.83 | 0.0898 |
| After treatment | 52.47±11.97 | 55.39±13.01 | 53.32±15.06 | 0.6103 |
| FEV1/FVC (%) (post-bronchodilator) | ||||
| Before treatment | 51.38±10.58 | 54.65±13.51 | 51.33±13.76 | 0.2968 |
| After treatment | 54.50±13.14 | 57.47±14.96 | 54.85±15.28 | 0.4328 |
| PEF(L/S) | ||||
| Before treatment | 3.30±1.54 | 3.32±1.48 | 3.14±1.57 | 0.854 |
| After treatment | 3.21±1.45 | 3.39±1.49 | 3.08±1.50 | 0.5612 |
| Frequency of acute exacerbation | ||||
| at 30days | 0.993 | |||
| 0 | 73(89.02%) | 81(92.05%) | 81(90.00%) | |
| once | 9(10.98%) | 5(5.68%) | 9(10.00%) | |
| twice | 0(0.00%) | 1(1.14%) | 0(0.00%) | |
| ≥three times | 0(0.00%) | 1(1.14%) | 0(0.00%) | |
| at 90days | 0.62 | |||
| 0 | 70(85.37%) | 65(79.27%) | 79(89.77%) | |
| once | 12(14.63%) | 17(20.73%) | 7(7.95%) | |
| twice | 0(0.00%) | 0(0.00%) | 2(2.27%) | |
| ≥three times | 0(0.00%) | 0(0.00%) | 0(0.00%) | |
| at 180days | 0.785 | |||
| 0 | 65(84.42%) | 74(89.16%) | 74(86.05%) | |
| once | 12(15.58%) | 8(9.64%) | 12(13.95%) | |
| twice | 0(0.00%) | 1(1.20%) | 0(0.00%) | |
| ≥three times | 0(0.00%) | 0(0.00%) | 0(0.00%) | |
| at 270days | 0.851 | |||
| 0 | 71(92.21%) | 77(92.77%) | 77(89.53%) | |
| once | 6(7.79%) | 5(6.02%) | 9(10.47%) | |
| twice | 0(0.00%) | 1(1.20%) | 0(0.00%) | |
| ≥three times | 0(0.00%) | 0(0.00%) | 0(0.00%) | |
| at 360days | 0.067 | |||
| 0 | 72(96.00%) | 69(87.34%) | 71(85.54%) | |
| once | 3(4.00%) | 10(12.66%) | 10(12.05%) | |
| twice | 0(0.00%) | 0(0.00%) | 2(2.41%) | |
| ≥three times | 0(0.00%) | 0(0.00%) | 0(0.00%) | |
| Score of SGRQ and descent range | ||||
| Score before treatment | 37.23±15.23 | 38.11±15.74 | 36.67±15.51 | 0.7602 |
| Descent range of 30days | 1.64±5.69 | 2.35±4.82 | 0.30±7.05 | 0.0525 |
| Score at 30days | 35.51±14.88 | 36.18±14.95 | 36.23±14.53 | 0.7778 |
| Descent range of 90days | 3.62±10.13 | 2.88±6.81 | 1.15±8.38 | 0.1321 |
| Score at 90days | 34.18±13.88 | 35.02±14.64 | 36.57±15.75 | 0.2358 |
| Descent range of 180days | 4.73±8.02 | 5.65±7.82 | 2.07±7.85 | 0.0115 |
| P<0.05 for BF VS Placebo, P<0.05 for BY VS Placebo, P>0.05 for BF VS BY | ||||
| Score at 180days | 33.66±15.74 | 33.13±14.53 | 34.56±15.13 | 0.6384 |
| Descent range of 270days | 4.87±8.05 | 5.59±9.52 | 3.92±7.09 | 0.508 |
| Score at 270days | 33.34±14.88 | 33.09±13.72 | 32.53±15.09 | 0.9976 |
| Descent range of 360days | 5.30±9.05 | 6.29±9.98 | 4.21±7.53 | 0.36 |
| Score at 360days | 33.07±14.86 | 32.91±14.05 | 33.10±14.49 | 0.9487 |