Table 3. Expressions of blood cytokines, Score of BODE, 6MWD, and Psychological field before and after treatment.

Variables	Per-protocol set
	BF tablet group	BY granule group	Placebo group	P-value
	n = 82	n = 89	n = 91
IL-6 (logarithm)
Before treatment	4.29±1.60	4.96±1.90	4.79±1.77	0.0912
After treatment	4.34±1.66	3.87±1.21	4.31±1.68	0.1776
IL-8 (logarithm)
Before treatment	5.18±2.11	5.79±2.30	5.69±2.35	0.1098
After treatment	5.00±2.03	4.96±1.83	4.67±1.92	0.7213
IL-10
Before treatment	48.00±117.16	73.73±223.03	269.81±1135.22	0.1668
After treatment	81.01±241.75	180.41±995.53	625.43±3620.71	0.4112
IL-17 (logarithm)
Before treatment	2.47±0.76	2.69±0.81	2.52±0.64	0.3463
After treatment	2.35±0.71	2.28±0.62	2.64±0.83	0.0219
	P<0.05 for A VS C, P<0.05 for BY VS Placebo
IL-1β(logarithm)
Before treatment	3.35±1.33	3.77±1.61	3.87±1.78	0.1013
After treatment	3.52±1.65	2.96±1.09	3.43±1.67	0.0776
TGF-β1 (logarithm)
Before treatment	9.13±0.66	9.23±0.59	9.06±1.28	0.6813
After treatment	9.04±0.81	9.07±0.84	9.01±0.71	0.9174
TNF-α(logarithm)
Before treatment	2.91±0.87	3.39±1.07	3.00±1.08	0.0563
After treatment	2.94±1.06	2.86±0.88	2.93±0.92	0.8333
Cortisol
Before treatment	25.23±12.73	23.97±11.27	25.61±12.67	0.5928
After treatment	26.46±17.49	29.59±21.48	22.43±11.85	0.2123
BODE score
Before treatment	3.22±1.91	3.14±1.98	3.12±1.56	0.8635
After treatment	2.90±1.78	2.61±1.80	2.54±1.63	0.3907
6MWD score
Before treatment	401.16±123.85	394.48±121.99	396.27±130.34	0.8416
90days	403.88±115.52	416.01±124.73	412.34±94.58	0.6493
180days	414.95±117.45	424.12±123.83	422.74±103.11	0.8462
Psychological field score
Before treatment	7.63±6.16	7.71±7.13	7.54±7.47	0.994
After treatment	4.78±4.02	6.30±8.40	6.92±9.50	0.1012