Figure 7. Acquired immunity is central for pathogenesis of nasally sensitized allergic rhinitis.

WT and Rag2 ^−/− mice were nasally administered ragweed (RW) pollen or PBS as in Figure 3A. (A, C) or for 7 consecutive days (B). (A) Number of sneezes. (B, C) Presence of eosinophils in nasal mucosa. Data representative of three independent experiments (means, SEMs n = 4). **P<0.01, ***P<0.001 (in (A), comparing WT to Rag2 ^−/− mice). ^†P<0.05, ^††P<0.01, ^†††P<0.001 (in (A), comparing to day 0 in Rag2 ^−/− mice).