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. 2014 Jul 15;7(7):1786–1793.

Table 2.

Correlation of the expression of the SHH signaling molecules SHH, PTCH, SMO, and GLI1, as well as p-STAT3 with clinicopathological features in PTC

SHH PTCH SMO GLI1 p-STAT3





Total - + ++ +++ - + ++ +++ - + ++ +++ - + ++ +++ - + ++ +++
Gender
    Female 121 34 40 33 14 42 39 31 9 37 39 32 13 41 43 31 6 47 47 26 1
    Male 43 15 18 8 2 17 15 8 3 14 17 9 3 18 12 10 3 24 10 6 3
Age
    ≤ 45 87 25 32 21 9 30 28 22 7 27 29 22 9 29 32 24 2 41 26 17 3
    > 45 77 24 26 20 7 29 26 17 5 24 27 19 7 30 23 17 7 30 31 15 1
Tumor Size
    ≤ 2 cm 84 31 29 16 8 41 24 14 5 37 25 15 7 38 22 20 4 39 29 14 2
    > 2 cm 80 18 29 25 8 18 30 25 7 14 31 26 9 21 33 21 5 32 28 18 2
ETE
    Yes 19 4 7 8 0 2 5 9 3 2 6 8 3 2 11 5 1 4 7 6 2
    No 145 45 51 33 16 57 49 30 9 49 50 33 13 57 44 36 8 67 50 26 2
LNM
    Yes 98 13 52 24 9 25 36 29 8 16 42 30 10 18 47 29 4 30 41 23 4
    No 66 36 6 17 7 34 18 10 4 35 14 11 6 41 8 12 5 41 16 9 0
TNM Stage
    I+II 112 39 32 28 13 48 42 17 5 41 43 23 5 46 33 27 6 57 34 18 3
    III+IV 52 10 26 13 3 11 12 22 7 10 13 18 11 13 22 14 4 14 23 14 1

ETE, extra thyroidal extension; LNM, lymph node metastasis.