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. 2014 May 28;4(8):1385–1394. doi: 10.1534/g3.114.011163

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Copyright © 2014 Colletti II et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Emca loci on mammary cancer multiplicity. Beginning at 9 wk of age, female rats of each of the indicated rat strains were treated with E2 released continuously from subcutaneous Silastic implants. Female rats from each congenic strain were evaluated contemporaneously with batches of ACI and BN rats. Because the mammary cancer phenotypes exhibited by susceptible ACI and resistant BN rats at each of the two institutions were highly reproducible, the individual batches of ACI and BN rats evaluated at each institution were pooled for comparison with congenic rats evaluated at the same institution. (A) Animals evaluated at the University of Nebraska Medical Center. (B) Animals evaluated at the University of Wisconsin-Madison. Each data bar indicates the mean tumor number (± SEM) observed at necropsy for rats treated for at least 160 days and no more than 201 days; n = 10−83 animals per group. Asterisks indicate statistical significance (P < 0.05) compared with ACI females evaluated at the same institution.