Table 3. Orthologous relationships between Emca susceptibility loci in rat and breast cancer risk loci in humans.

Locus	Peak LOD Marker	Proximal 95% Confidence Interval Marker	Distal 95% Confidence Interval Marker	Human Locus	SNP	Chr. Position of Human SNP	Gene	Orthologous Rat Position, Mb	Reference
Emca3	D2Rat16	−	−	5q11	rs1353747	58337481	PDE4D	41.3	Michailidou et al. 2013
	43.4 Mb			5q11	rs10472076	58184061	RAB3C	41.4	Michailidou et al. 2013
				5q11	rs889312	56031884	MAP3K1, MIER3	43.2	Easton et al. 2007; Turnbull et al. 2010
				5q11	rs16886165	56023083	MAP3K1	43.2	Thomas et al. 2009
				5q11	rs30099	52418582	−	46.9	Easton et al. 2007
				5p12	rs981782	45285718	−	49.9	Easton et al. 2007
				5p12	rs2067980	44982317	MRPS30	50.3	Thomas et al. 2009
				5p12	rs7716600	44875005	MRPS30	50.5	Thomas et al. 2009
				5p12	rs10941679	44706498	MRPS30, HCN1	50.6	Stacey et al. 2008; Thomas et al. 2009
Emca4	D7Rat19	D7Rat44	D7Rat15	8q24	rs13281615	128355618	MYC	98.4	Easton et al. 2007
	98.6 Mb	66.2 Mb	107.4 Mb	8q24	rs1562430	128387852	MYC	98.5	Thomas et al. 2009; Turnbull et al. 2010
				8q24	rs11780156	129194641	MIR1208	99.3	Michailidou et al. 2013
Emca5	D3Rat114	D3Rat227	D3Rat210	2q31	rs2016394	172972971	METAP1D	53.9	Michailidou et al. 2013
	149.5 Mb	41.1 Mb	156.6 Mb	2q31	rs1550623	174212894	CDCA7	54.9	Michailidou et al. 2013
				8p12	rs9693444	29509616	−	63.2	Michailidou et al. 2013
				20q11	rs2284378	32588095	RALY	145.3	Siddiq et al. 2012
Emca6	D4Rat103	D4Rat14	D4Rat202	7q35	rs720475	144074929	ARHGEF5, NOBOX	71.1	Michailidou et al. 2013
	82.7Mb	41.7Mb	159.1 Mb	3p26	rs6762644	4742276	ITPR1, EGOT	143.9	Michailidou et al. 2013
Emca7	D6Rat22	D6Rat68	D6Rat81	2p24	rs4666451	19286943	−	33.3	Easton et al. 2007
	75.5 Mb	2.8 Mb	112.0 Mb	2p24	rs12710696	19320803	−	33.3	Garcia-Closas et al. 2013
				14q13	rs2236007	37132769	PAX9, SLC25A21	77.1	Michailidou et al. 2013
				14q24	rs2588809	68660428	RAD51L1	102.5	Michailidou et al. 2013
				14q24	rs999737	69034382	RAD51B	103.9	Thomas et al. 2009
				14q32	rs941764	91841069	CCDC88C	125.3	Michailidou et al. 2013
Emca8	D5Rat95	D5Rat134	D5Rat37	9q31	rs10759243	110306115	−	73.5	Michailidou et al. 2013
	130.6 Mb	52.43 Mb	148.5 Mb	9p21	rs1011970	22062134	CDKN2A, CDKN2B	109.0	Turnbull et al. 2010
				1p36	rs616488	10566215	PEX14	166.1	Michailidou et al. 2013
Emca9	D18Rat30	−	−	18q11	rs527616	24337424	−	6.5	Michailidou et al. 2013
	5.7 Mb			18q11	rs1436904	24570667	CHST9	6.8	Michailidou et al. 2013

LOD, logarithm of odds ratio; SNP, single-nucleotide polymorphism.