Table 4.
Models of stroke: correlations between biochemical markers, functional evaluation, volume of infarct and cell death
|
Correlations: values of spearman R |
IL-6 |
TNF-α |
Glutamate |
|||
|---|---|---|---|---|---|---|
| IL-6 3h | IL-6 72h | TNF-α 3h | TNF-α 72h | Glu 3h | Glu 72 h | |
|
Clinical score pre-euthanasia (72 h) |
0.171 |
−0.600 |
0.348 |
−0.522 |
0.429 |
0.388 |
| 0.507 |
0.169 |
0.676 |
0.338 |
−0.169 |
0.169 |
|
|
Volume of infarct as percentage of contralateral hemisphere |
0.348 |
0.319 |
−0.088 |
−0.794 |
0.116 |
0.943*** |
| 0.058 |
−0.087 |
0.522 |
0.000 |
−0.232 |
0.232 |
|
|
Cell death TUNEL in cortex |
0.928*** |
−0.058 |
0.765* |
−0.353 |
0.783* |
0.486 |
| TUNEL in striatum † | −0.714 |
−0.257 |
−0.714 |
−0.886** |
0.086 |
−0.257 |
| −0.580 |
0.290 |
−0.294 |
−0.177 |
−0.348 |
0.429 |
|
| - | - | - | - | - | - | |
The upper line of each row corresponds to the embolic stroke (ES) model and the line below to the permanent middle cerebral artery occlusion (pMCAO) model. *P < 0.1; **P < 0.05; ***P < 0.01. Results with P< 0.1 are in bold
† The pMCAO model presents infarctions affecting the cortex but not the striatum.