Table 2.
Model selection for time to distant intracranial progression
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| |
HR |
95% CI |
p value |
HR |
95% CI |
p value |
| Age at SRS >60 years |
0.66 |
0.43 – 1.01 |
0.05 |
0.64 |
0.41 – 0.99 |
0.05 |
| Time from primary to brain met <39 mo. |
1.16 |
0.76 – 1.77 |
0.50 |
|
|
|
| Extensive ECM (vs. Limited)* |
1.20 |
0.77 – 1.89 |
0.43 |
|
|
|
| Progressive ECD (vs. absent/stable) |
1.15 |
0.70 – 1.87 |
0.58 |
|
|
|
| Number of brain metastases >1 |
1.45 |
0.93 – 2.24 |
0.10 |
1.90 |
1.18 – 3.06 |
0.008 |
| Diameter of brain metastasis >1 cm |
0.85 |
0.55 – 1.30 |
0.44 |
|
|
|
| KPS 50 – 80 (vs. 90 or 100) |
0.90 |
0.58 – 1.41 |
0.65 |
|
|
|
| Omission of up-front WBRT | 1.54 | 0.91 – 2.60 | 0.09 | 2.24 | 1.27 – 3.94 | 0.005 |
Abbreviations:HR hazard ratio, CI confidence interval, SRS stereotactic radiosurgery, Met metastasis, ECM extracranial metastases, ECD extracranial disease, KPS Karnofsky Performance Status, WBRT whole brain radiation therapy.
*See Materials and Methods section and Table 1 for definitions of “extensive” and “limited” extracranial metastases.