Table 2.
Antimicrobial susceptibility to 2 nd generation fluoroquinolones and its relation with biofilm production in 66 E. coli isolates from dogs with urinary infections
| |
|
Fluoroquinolones |
|||
|---|---|---|---|---|---|
| CIP | ENR | MAR | OBX | ||
| Susceptibility criteria (μg/mL)a |
Susceptible; Resistant |
≤ 1; ≥ 4 |
≤ 0.5; ≥ 4 |
≤ 1; ≥ 4 |
≤ 1; ≥ 8 |
| Susceptibility results |
Susceptible |
57 (86.4%) |
57 (86.4%) |
57 (86.4%) |
56 (84.8%) |
| |
Resistant |
9 (13.6%) |
9 (13.6%) |
9 (13.6%) |
10 (15.2%) |
| Relation with biofilm production | P < 0.05 | P < 0.05 | P < 0.05 | P < 0.05 | |
aIsolates that were categorized as intermediate to the antimicrobial compounds were recorded as susceptible, since the bactericidal activity of these antimicrobials depends of their in vivo concentration and quinolones are known to be concentrated from 100- to 300-fold within the urinary tract (Cohn and others 2003); CIP Ciprofloxacin (CLSI 2014), ENR Enrofloxacin (CLSI 2013), MAR Marbofloxacin (CLSI 2013), OBX Orbifloxacin (CLSI 2013).