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Analysis of binding kinetics measured by surface plasmon resonance.
| Construct | Kon (S-1 M-1) | Koff (S-1) | KD (nM) |
|---|---|---|---|
| hu3F8 | 1.15 × 105 | 1.04 × 10-3 | 9.1 |
| V3 | 1.09 × 105 | 1.25 × 10-3 | 11.5 |
| V3-Ile | 1.28 × 105 | 0.48 × 10-3 | 3.7 |
| V5 | 1.73 × 105 | 3.30 × 10-3 | 19.1 |
Kon and Koff were determined from individual sensorgrams, shown in Figure S1 in Supplementary Material.
