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. 2014 Aug 14;5:388. doi: 10.3389/fimmu.2014.00388

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Copyright © 2014 Toh, Gan, Balakrishnan, Zuest, Poidinger, Wilson, Appanna, Thein, Ong, Ng, Leo and Fink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The EDIII-specific antibody titers vary substantially between patients and are not long-lasting. Plasma samples from patients with primary or secondary infection were analyzed for binding to E and EDIII protein and each patient’s antibody binding profile is shown individually by connected symbols. The mean values for the same data are shown in Figures 1B,C. (A) Individual curves for binding to DENV-2 E and EDIII protein. (B) Individual curves for binding to DENV-1 E and EDIII protein. The dashed lines indicate values for pooled neg. and positive control plasma, respectively. Mouse mAb 3H5 was used as a positive control for the DENV-2 EDIII ELISA because the pooled positive plasma did not show more binding to DENV-2 EDIII than the pooled negative plasma. The use of a different positive controls for DENV-1 and DENV-2 resulted in OD ratios of a different scale for the two EDIII ELISAs.