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Age-dependent reduction of rCBF in wild type and APP DSL mice measured by MRI. A. Representative CBF maps for wild type (WT) and APP DSL knock-in mice at young, middle, and old ages. B. Quantification of CBF in the cortical area of MRI scans. N = 5-8 mice/genotype/age. NS, not significant; *P < 0.05, **P < 0.01.
