Table 5.
Factors affecting overall in-hospital mortality of the CVP-BSI group
| Factor | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Underlying disease | ||||||
| No | 1.000 | - | - | - | - | - |
| Yes | 1.654 | 0.623-4.397 | 0.313 | - | - | - |
| Recent transfusiona) | ||||||
| No | 1.000 | - | - | 1.000 | - | - |
| Yes | 4.545 | 1.639-12.606 | 0.004 | 2.975 | 1.015-8.719 | 0.047 |
| Cancer type | ||||||
| Non-gastrointestinal | 1.000 | - | - | - | - | - |
| Gastrointestinal | 1.580 | 0.577-4.327 | 0.373 | - | - | - |
| Disease status | ||||||
| Localized | 1.000 | - | - | - | - | - |
| Metastatic | 1.746 | 0.637-4.786 | 0.279 | - | - | - |
| Monthly catheter utilization days | ||||||
| < 7 days | 1.000 | - | - | - | - | - |
| ≥ 7 days | 2.066 | 0.667-6.402 | 0.209 | - | - | - |
| Hospital stay at last month (≥ total 7 days) | ||||||
| No | - | - | 1.000 | - | - | |
| Yes | 1.062-60.547 | 0.044 | 3.917 | 0.463-33.104 | 0.210 | |
| DIC profile | ||||||
| Negative | - | - | - | - | - | |
| Positive | 0.403-3.431 | 0.767 | - | - | - | |
| Combined infection | ||||||
| No | 0.133-1.051 | 0.062 | - | - | - | |
| Yes | - | - | - | - | - | |
| Gram-positive cocci | ||||||
| No | - | - | - | - | - | |
| Yes | 0.265-2.170 | 0.605 | - | - | - | |
| Gram-negative rod | ||||||
| No | - | - | - | - | - | |
| Yes | 0.290-2.079 | 0.615 | - | - | - | |
| Fungus | ||||||
| No | - | - | - | - | - | |
| Yes | 0.545-3.808 | 0.461 | - | - | - | |
| Polymicrobial | ||||||
| No | - | - | - | - | - | |
| Yes | 0.782-5.928 | 0.138 | - | - | - | |
| Time to first antibiotics | ||||||
| > 4 hr | - | - | - | - | - | |
| ≤ 4 hr | 0.336-2.923 | 0.986 | - | - | - | |
| Early CVP removal | ||||||
| Yes (< 48 hr) | - | - | - | - | - | |
| No (≥ 48 hr) | 0.755-6.036 | 0.153 | - | - | - | |
| Initial antibiotics | ||||||
| < 4 hr | 0.336-2.923 | 0.986 | - | - | - | |
| ≥ 4 hr | - | - | - | - | - | |
| Shock | ||||||
| No | 0.044-2.562 | 0.292 | - | - | - | |
| Yes | - | - | - | - | - | |
| Neutropenia G3-G4 | ||||||
| No | 0.342 | 0.045-2.588 | 0.299 | - | - | - |
| Yes | 1.000 | - | - | - | - | - |
| Central venous port duration | ||||||
| < 30 days | 1.000 | - | - | - | - | - |
| ≥ 30 days | 0.849 | 0.298-2.414 | 0.758 | - | - | - |
| Total parenteral nutrition | ||||||
| No | 1.000 | - | - | 1.000 | - | - |
| Yes | 3.833 | 1.246-11.788 | 0.019 | 2.729 | 0.838-8.890 | 0.096 |
CVP-BSI, central venous port-related bloodstream infection; HR, hazard ratio; CI, confidence interval; DIC, disseminated intravascular coagulation.
a)
Recent transfusion: transfusion between admission and occurrence of CVP-BSI.