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Tumor budding in Barrett’s carcinoma. (A) Poorly differentiated adenocarcinoma of the esophagus with signet cell component as seen in a pancytokeratin (top) and H&E (bottom) stain (250×). Tumor buds cannot be differentiated by morphology from the diffusely infiltrating tumor mass. (B) Intestinal type adenocarcinoma of the esophagus with presence of tumor buds at the invasive front as seen in a pancytokeratin (top) and H&E (bottom) stain (250×).
