Table 3.
Significant biological processes of the low TO genes that have a larger number of links in the coexpression network of a particular region.
| Number of low TO genes |
Number of genes with high connectivity in region |
Significant biological processes/pathways |
|---|---|---|
| 204 EC-HIP | 115 genes in EC | Regulation of response to stress |
| Cell adhesion-ephrin signaling | ||
| Apoptosis and survival-NO synthesis and signaling | ||
| Cell cycle-chromosome condensation in prometaphase | ||
| 95 genes in HIP | Mitochondrial translational termination | |
| Regulation of protein exit from endoplasmic reticulum | ||
| DNA damage-ATM/ATR regulation of G1/S checkpoint | ||
| Immune response | ||
|
| ||
| 140 EC-MTG | 84 genes in EC | Cell adhesion |
| Signal transduction cAMP signaling | ||
| Positive regulation of transcription elongation from RNA polII promoter | ||
| Regulation of transcription involved in G1 phase (mitotic cell cycle) | ||
| Regulation of G2/M transition of mitotic cell cycle | ||
| Apoptosis and survival | ||
| 56 genes in MTG | Negative regulation of stress activated MAPK cascade | |
| Negative regulation of signal transduction | ||
| Activation of astroglial cells proliferation by ACM3 | ||
| Notch signaling pathway | ||
| Regulation of lipid metabolism | ||
|
| ||
| 242 EC-PCC | 130 genes in EC | Generation of signal involved in cell-cell signaling |
| Positive regulation of mitotic cell cycle | ||
| 118 genes in PCC | Proteolysis role of parkin | |
| Immune response IL6 signaling pathway | ||
| p53 signaling pathway | ||
| Activation of ESR1/SP pathway | ||
|
| ||
| 125 HIP-MTG | 59 genes in HIP | Oxidative phosphorylation |
| Neuroligin clustering | ||
| Gephyrin clustering | ||
| Postsynaptic membrane assembly | ||
| Cholesterol and sphingolipids transport | ||
| 66 genes in MTG | Transcription | |
| GTP-XTP metabolism | ||
| ATP/ITP metabolism | ||
| Osmosensory signaling pathway | ||
| Ribonucleotide metabolic process | ||
|
| ||
| 312 HIP-PCC | 145 genes in PCC | Cell adhesion-ephrin signaling |
| Immune response | ||
| Negative adaptation of signaling pathway | ||
| 174 genes in HIP | Memory and learning | |
| Regulation of dopamine metabolic process | ||
| Cognition | ||
| Regulation of calcium ion transport | ||
| NMDA-dependent postsynaptic long-term potentiation | ||
| DNA damage, apoptosis, and survival | ||
|
| ||
| 158 PCC-MTG | 83 genes in PCC | Positive regulation of protein tyrosine kinase activity |
| Neural plate elongation | ||
| Ubiquinone metabolism | ||
| PEDF signaling | ||
| Cytoskeleton remodeling-RalB regulation pathway | ||
| Antiapoptotic TNFs/NF-kB/IAP pathway | ||
| 77 genes in MTG | Glucocorticoid receptor signaling | |
| Positive regulation of transport | ||