Table 4.
Disease associations of sets of low TO genes with (extended set) and without (primary set) their direct neighbors in the PPI networks.
| Region PPI network | Disease association of low TO genes and neighbors in PPI net |
Disease association of low TO genes only |
|---|---|---|
| EC-HIP | Cluster 1 enrichment score = 0.96 | Cluster 1 |
| Hypertension | Cardiovascular | |
| Arterial disease | ||
| Atherosclerosis | ||
| Kidney disease | ||
| Vascular dementia | ||
| Diabetic nephropathy | ||
|
| ||
| EC-PCC | Cluster 1 enrichment score = 0.93 | Cluster 1 |
| Hyperlipidemia | Ischemic stroke, renal, atherosclerosis | |
| Coronary artery disease risk | ||
| Cholesterol | ||
| Cluster 2 enrichment score = 0.91 | Cluster 2 | |
| Heart related conditions | Cancer | |
| Alzheimer's disease | Macular degeneration | |
|
| ||
| EC-MTG | Cluster 1 enrichment score = 0.89 | |
| Insulin, cholesterol | ||
| Type 2 diabetes, hypertension | ||
| Polycystic ovary syndrome | ||
|
| ||
| HIP-PCC | Cluster 1 enrichment score = 0.82 | Cluster 1 |
| Colon cancer, rectal cancer | Crohn's disease, atherosclerosis, ischemic stroke, renal | |
|
| ||
| PCC-MTG | Cluster 1 enrichment score = 0.99 | |
| Type 2 diabetes | ||
| Hypertension | ||
| Cholesterol | ||
| Polycystic ovary syndrome | ||
|
| ||
| HIP-MTG | Cluster 1 enrichment score = 1.23 | |
| Colon cancer, rectal cancer | ||
| Male infertility | ||
The low TO genes are proteins in the region PPI network. Column 1 shows the diseases associated with the low TO proteins and their direct neighbors in the regional PPI network while column 2 shows the diseases associated with only the low TO genes (without their neighbors). Disease databases used: OMIM disease, genetic association disease database. Similarity threshold for clustering = 0.80. Results reported only for the clusters with enrichment score 0.8 or higher. In this analysis, the low TO genes were not divided into 2 groups based on which regional coexpression network they had a higher connectivity in.