Table 6.
Disease association of the pairs of low TO gene modules in Soler-López et al.'s AD PPI network.
| Number of overlapping low TO genes |
Number of low TO genes with high connectivity in region (number of proteins in low TO modules) |
Enriched disease clusters |
|---|---|---|
| 15 EC-HIP | 9 + 1 low TO genes in EC (67 proteins) | Cluster 1 enrichment score = 1.88 |
| Arterial disease | ||
| Atherosclerosis, generalized blood pressure | ||
| Arterial cardiovascular disease | ||
| Cerebral white matter lesions | ||
| Esophageal varices | ||
| Peritoneal transport | ||
| 5 + 1 low TO genes in HIP (35 proteins) | None | |
|
| ||
| 21 EC-MTG | 12 + 0 low TO genes in EC (60 proteins) | None |
| 9 + 0 low TO genes in MTG (125 proteins) | None | |
|
| ||
| 23 EC-PCC | 12 + 0 low TO genes in EC (66 proteins) | None |
| 11 + 0 low TO genes in PCC (88 proteins) | Cluster 1 enrichment score = 0.98 | |
| Coronary atherosclerosis | ||
| Lipoprotein | ||
| Cardiovascular disease | ||
| Myocardial infarction | ||
| Cluster 2 enrichment score = 0.88 | ||
| Lipoprotein | ||
| Myocardial infarction | ||
| Coronary artery disease | ||
| Atherosclerosis, coronary | ||
|
| ||
| 12 HIP-MTG | 5 + 0 low TO genes in HIP (18 proteins) | Cluster 1 enrichment score = 0.9 |
| Prostate cancer | ||
| Breast cancer | ||
| Pharmacogenomic | ||
| Cancer | ||
| 7 + 0 low TO genes in MTG (37 proteins) | None | |
|
| ||
| 27 HIP-PCC | 12 + 1 low TO genes in PCC (58 proteins) | Cluster 1 enrichment score = 1.58 |
| Coronary artery disease | ||
| Stroke | ||
| Crohn's disease ulcerative colitis | ||
| Restenosis | ||
| Cluster 2 enrichment score = 0.83 | ||
| Melanoma | ||
| Stomach cancer | ||
| Asthma | ||
| 14 + 1 low TO genes in HIP (95 proteins) | None | |
|
| ||
| 16 PCC-MTG | 6 + 1 low TO genes in PCC (47 proteins) | None |
| 9 + 1 low TO genes in MTG (112 proteins) | None | |
Number of low TO genes with high connectivity in regional coexpression network = number of low TO genes with higher connectivity in one brain region + number of low TO genes with equal connectivity in both brain regions. There are 1704 proteins in ADnet. In EC HIP, 204 low TO genes ⋂ ADnet = 15 proteins. In EC MTG, 140 low TO genes ⋂ ADnet = 21 proteins. In EC PCC, 242 low TO genes ⋂ ADnet = 23 proteins. In HIP MTG, 125 low TO genes ⋂ ADnet = 12 proteins. In HIP PCC, 312 low TO genes ⋂ ADnet = 27 proteins. In PCC MTG, 158 low TO genes ⋂ ADnet = 16 proteins. Disease annotation cluster analysis was conducted on pairs of exclusive low TO modules (pairs of low TO modules excluding common proteins between module pairs). MTG seems to be least associated with cardiovascular diseases (CVD). When comparing EC and HIP, EC is highly associated with CVD. When comparing EC and PCC, PCC is highly associated with CVD. When comparing HIP and PCC, PCC is highly associated with CVD.