Table 1.
Changes in protein expression in hippocampus and cerebellum of IL-6 and CCL2 transgenic mice.
| IL-6 | CCL2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hippocampus | Cerebellum | Hippocampus | Cerebellum | |||||||||
| Protein | 1–2 months | 3–5 months | 12 months | 1–2 months | 3–5 months | 12 months | 1–2 months | 3–5 months | 7–9 months | 1–2 months | 3–5 months | 7–9 months |
| β-actin | none | none | none | none | ▲ | none | none | none | none | none | none | nd |
| GFAP | ▲ | ▲ | ▲ | ▲ | ▲ | ▲ | none | none | none | none | none | nd |
| Glu syn | none | none | none | ▲ | ▲ | none | none | none | none | none | none | nd |
| Enolase | none | none | none | ▼ | none | none | none | none | none | none | none | nd |
| p42 MAPK | none | none | none | none | none | none | none | none | none | none | none | nd |
| p44 MAPK | none | none | none | none | none | none | none | none | none | none | none | nd |
| STAT3 | ▲ | ▲ | ▲ | ▲ | ▲ | ▲ | none | nd | none | none | none | nd |
| C/EBPβ | none | none | none | ▲ | none | none | none | nd | none | none | none | nd |
| Synapsin 1 | none | none | ▼ | ▼ | ▼ | ▼ | none | none | none | none | none | nd |
| GAD65/67 | none | ▼ | none | ▼ | ▼ | ▼ | none | none | ▼ | none | none | nd |
| GluA1 | none | none | none | ▼ | ▼ | nd | none | none | none | none | none | nd |
| GluN1 | none | none | ▼ | ▼ | ▼ | nd | none | ▲ | none | none | none | nd |
* for each group, tg is compared to non-tg; ▲ = tg > non-tg; ▼ = tg < non-tg; none = no significant difference between tg and non-tg; nd = not determined.