Table 2.

Association of plasma CXCL12 with prevalent cardiovascular disease^a (CVD) at baseline

Model (total n = 3687)	Odds ratio (95% CI)b	P value	Odds ratio (95% CI)c	P value
Model 1	1.42 (1.32, 1.53)	<0.001	1.81 (1.56, 2.09)	<0.001
Model 2	1.36 (1.26, 1.46)	<0.001	1.66 (1.43, 1.93)	<0.001
Model 3	1.30 (1.20, 1.40)	<0.001	1.53 (1.31, 1.78)	<0.001
Model 4	1.23 (1.14, 1.33)	<0.001	1.38 (1.18, 1.62)	<0.001

Model 1: CXCL12 + demographic factors (age, sex, race).

Model 2: CXCL12 + demographic factors + traditional risk factors (diabetes, hypertension, hypercholesterolaemia, tobacco use, body mass index).

Model 3: CXCL12 + demographic factors + traditional risk factors + plasma inflammatory biomarkers (log transformed IL6, TNFα, and high-sensitivity C-reactive protein).

Model 4: CXCL12 + demographic factors + traditional risk factors + plasma inflammatory biomarkers + kidney function measures (CRIC-defined estimated glomerular filtration rate²¹ and log-transformed urinary albumin:creatinine ratio).

^aPrevalent CVD is defined as prior MI or coronary revascularization (n with any CVD = 1232; n without CVD = 2455).

^bFor one standard deviation increase in a plasma CXCL12.

^cFor plasma CXCL12 levels above the median cut point value of 2.432 ng/mL.